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Fertil Steril. 2010 Apr;93(6):2004-11. doi: 10.1016/j.fertnstert.2008.12.059. Epub 2009 Jan 30.

Association of adolescent obesity and lifetime nulliparity--the Study of Women's Health Across the Nation (SWAN).

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  • 1Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA. apolotsky@yahoo.com

Abstract

OBJECTIVE:

To evaluate whether adolescent obesity is associated with difficulties in becoming pregnant later in life.

DESIGN:

Cross-sectional analysis of baseline data from a longitudinal cohort.

SETTING:

Multiethnic, community-based observational study of U.S. women.

PATIENT(S):

Three thousand one hundred fifty-four midlife women.

MAIN OUTCOME MEASURE(S):

Lifetime nulliparity and lifetime nulligravidity.

RESULT(S):

Five hundred twenty-seven women (16.7%) women had never delivered a baby. Participants were categorized by self-reported high school body mass index (BMI): underweight (<18.5 kg/m(2)), normal (18.5-24.9 kg/m(2)), overweight (25-29.9 kg/m(2)), and obese (>30 kg/m(2)). The prevalence of lifetime nulliparity increased progressively across the high school BMI categories: 12.7%, 16.7%, 19.2%, and 30.9%, respectively. Multivariable logistic regression analysis confirmed that women who were obese adolescents had significantly higher odds of remaining childless compared with normal weight women (odds ratio [OR] 2.84; 95% confidence interval [CI], 1.59-5.10) after adjusting for adult BMI, history of nongestational amenorrhea, marital status, ethnicity, study site, and measures of socioeconomic status. Furthermore, adolescent obesity was associated with lifetime nulligravidity (OR = 3.93; 95% CI, 2.12-7.26).

CONCLUSION(S):

Adolescent obesity is associated with lifetime nulliparity and nulligravidity in midlife U.S. women.

Copyright 2010 American Society for Reproductive Medicine. All rights reserved.

PMID:
19185860
[PubMed - indexed for MEDLINE]
PMCID:
PMC2891509
Free PMC Article

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