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RNA Biol. 2008 Jul-Sep;5(3):115-9.

The emerging role of miR-200 family of microRNAs in epithelial-mesenchymal transition and cancer metastasis.

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  • 1Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.

Abstract

MicroRNAs (miRNAs) play essential roles in many physiological and pathological processes, including tumor development, by regulating the expression of a plethora of mRNAs. Although the importance of miRNAs in tumorigenesis is well established, only recently have reports elucidated miRNAs as promoters or suppressors of metastasis. The miR-200 family has been shown to inhibit the initiating step of metastasis, epithelial-mesenchymal transition (EMT), by maintaining the epithelial phenotype through direct targeting of transcriptional repressors of E-cadherin, ZEB1 and ZEB2. These findings shed light into a miRNA-mediated regulatory pathway that influences EMT in a developmentally and pathologically relevant setting.

PMID:
19182522
PMCID:
PMC3532896
[PubMed - indexed for MEDLINE]
Free PMC Article
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