Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Br J Psychiatry. 2009 Feb;194(2):123-9. doi: 10.1192/bjp.bp.108.051359.

Age-related grey matter volume correlates of response inhibition and shifting in attention-deficit hyperactivity disorder.

Author information

  • 1Department of Psychiatry, University of Hong Kong, Pokfulam, Hong Kong. mcalonan@hkucc.hku.hk

Abstract

BACKGROUND:

Children with attention-deficit hyperactivity disorder (ADHD) have difficulties with executive function and impulse control which may improve with age.

AIMS:

To map the brain correlates of executive function in ADHD and determine age-related changes in reaction times and brain volumes.

METHOD:

Attention-deficit hyperactivity disorder and control groups were compared on the change task measures of response inhibition (stop signal reaction time, SSRT) and shifting (change response reaction time, CRRT). Voxel-wise magnetic resonance imaging (MRI) correlations of reaction times and grey matter volume were determined, along with bivariate correlations of reaction times, brain volumes and age.

RESULTS:

Individuals in the ADHD group had longer SSRTs and CRRTs. Anterior cingulate, striatal and medial temporal volumes highly correlated with SSRT. Striatal and cerebellar volumes strongly correlated with CRRT. Older children had faster reaction times and larger regional brain volumes. In controls, orbitofrontal, medial temporal and cerebellar volumes correlated with CRRT but not SSRT. Neither reaction times nor regional brain volumes were strongly age-dependent.

CONCLUSIONS:

Our evidence supports delayed brain maturation in ADHD and implies that some features of ADHD improve with age.

PMID:
19182173
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk