Nat Rev Drug Discov. 2009 Feb;8(2):129-38.

Knocking down barriers: advances in siRNA delivery.

Source

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.

Erratum in

Nat Rev Drug Discov. 2009 Jun;8(6):516.

Abstract

In the 10 years that have passed since the Nobel prize-winning discovery of RNA interference (RNAi), billions of dollars have been invested in the therapeutic application of gene silencing in humans. Today, there are promising data from ongoing clinical trials for the treatment of age-related macular degeneration and respiratory syncytial virus. Despite these early successes, however, the widespread use of RNAi therapeutics for disease prevention and treatment requires the development of clinically suitable, safe and effective drug delivery vehicles. Here, we provide an update on the progress of RNAi therapeutics and highlight novel synthetic materials for the encapsulation and intracellular delivery of nucleic acids.

PMID:: 19180106; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Education

New England Research Institutes Inc.

Supplemental Content

Save items

Related citations in PubMed

Review Polycation-based nanoparticle delivery for improved RNA interference therapeutics. [Expert Opin Biol Ther. 2007]
Review Polycation-based nanoparticle delivery for improved RNA interference therapeutics.
Howard KA, Kjems J. Expert Opin Biol Ther. 2007 Dec; 7(12):1811-22.
Harnessing RNA interference to develop neonatal therapies: from Nobel Prize winning discovery to proof of concept clinical trials. [Early Hum Dev. 2009]
Harnessing RNA interference to develop neonatal therapies: from Nobel Prize winning discovery to proof of concept clinical trials.
DeVincenzo JP. Early Hum Dev. 2009 Oct; 85(10 Suppl):S31-5. Epub 2009 Oct 14.
Review Delivery vehicles for small interfering RNA in vivo. [Hum Gene Ther. 2008]
Review Delivery vehicles for small interfering RNA in vivo.
de Fougerolles AR. Hum Gene Ther. 2008 Feb; 19(2):125-32.
Review Nonviral in vivo delivery of therapeutic small interfering RNAs. [Curr Opin Mol Ther. 2007]
Review Nonviral in vivo delivery of therapeutic small interfering RNAs.
Aigner A. Curr Opin Mol Ther. 2007 Aug; 9(4):345-52.
Review Delivering small interfering RNA for novel therapeutics. [Methods Mol Biol. 2008]
Review Delivering small interfering RNA for novel therapeutics.
Lu PY, Woodle MC. Methods Mol Biol. 2008; 437:93-107.

See reviews... See all...

Cited by 70 PubMed Central articles

Nanotechnology and the Treatment of HIV Infection. [Viruses. 2012]
Nanotechnology and the Treatment of HIV Infection.
Parboosing R, Maguire GE, Govender P, Kruger HG. Viruses. 2012 Apr; 4(4):488-520. Epub 2012 Apr 10.
Low molecular weight chitosan nanoparticulate system at low N:P ratio for nontoxic polynucleotide delivery. [Int J Nanomedicine. 2012]
Low molecular weight chitosan nanoparticulate system at low N:P ratio for nontoxic polynucleotide delivery.
Alameh M, Dejesus D, Jean M, Darras V, Thibault M, Lavertu M, Buschmann MD, Merzouki A. Int J Nanomedicine. 2012; 7:1399-414. Epub 2012 Mar 13.
Nanomedicines based on recombinant fusion proteins for targeting therapeutic siRNA oligonucleotides. [Ther Deliv. 2011]
Nanomedicines based on recombinant fusion proteins for targeting therapeutic siRNA oligonucleotides.
Winkler J. Ther Deliv. 2011 Jul; 2(7):891-905.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Knocking down barriers: advances in siRNA delivery.
Knocking down barriers: advances in siRNA delivery.
Nat Rev Drug Discov. 2009 Feb ;8(2):129-38.

PubMed
SPIDER image processing for single-particle reconstruction of biological macromo...
SPIDER image processing for single-particle reconstruction of biological macromolecules from electron micrographs.
Nat Protoc. 2008 ;3(12):1941-74.

PubMed
A statewide intervention reduces BMI in adults: Shape Up Rhode Island results.
A statewide intervention reduces BMI in adults: Shape Up Rhode Island results.
Obesity (Silver Spring). 2009 May ;17(5):991-5. Epub 2009 Jan 29 .

PubMed
A serine esterase released by human alveolar macrophages is closely related to l...
A serine esterase released by human alveolar macrophages is closely related to liver microsomal carboxylesterases.
J Biol Chem. 1991 Oct 5 ;266(28):18832-8.

PubMed
Primary Sjögren's syndrome mimicking lymphoma in a pediatric patient. A rare and...
Primary Sjögren's syndrome mimicking lymphoma in a pediatric patient. A rare and possibly misdiagnosed condition.
Minerva Pediatr. 2009 Feb ;61(1):119-22.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: