Obesity (Silver Spring). 2009 Apr;17(4):713-22. doi: 10.1038/oby.2008.637. Epub 2009 Jan 29.

One-year weight losses in the Look AHEAD study: factors associated with success.

Wadden TA, West DS, Neiberg RH, Wing RR, Ryan DH, Johnson KC, Foreyt JP, Hill JO, Trence DL, Vitolins MZ; Look AHEAD Research Group.

Collaborators (369)

Brancati FL, Honas J, Cheskin L, Clark JM, Stewart K, Rubin R, Charleston J, Horak K, Bray GA, Rau K, Strate A, Armand B, Greenway FL, Ryan DH, Williamson D, Bachand A, Begnaud M, Berhard B, Cadarette E, Cerniauskas B, Creel D, Crow D, Guay H, Kora N, LaFleur K, Landry K, Lingle M, Perault J, Shipp M, Smith M, Tucker E, Lewis CE, Thomas S, Safford M, DiLillo V, Bragg C, Dobelstein A, Gilbert S, Glasser S, Hannum S, Hubbell A, Jones J, Lee D, Luketic R, Marshall K, Oden LC, Raines J, Roche C, Truman J, Webb N, Wrenn A, Nathan DM, Turgeon H, Schumann K, Cagliero E, Delahanty L, Hayward K, Anderson E, Bissett L, Ginsburg R, Goldman V, Harlan V, McKitrick C, McNamara A, Michel T, Poulos A, Steiner B, Tosch J, Horton ES, Jackson SD, Hamdy O, Caballero AE, Bain S, Bovaird E, Geobel-Fabbri A, Lambert L, Ledbury S, Malloy M, Ovalle K, Blackburn G, Mantzoros C, Day K, McNamara A, Hill JO, Miller M, Phillipp J, Schwartz R, Van Dorsten B, Regensteiner J, Benchekroun S, Coelho L, Cohrs P, Daeninck E, Fields A, Green S, Hamilton A, Hamilton J, Leshchinskiy E, McDermott M, Munkwitz L, Rome L, Wallace K, Worley T, Foreyt JP, Reeves RS, Pownall H, Balasubramanyam A, Jones P, Burrington M, Chen CH, Clark A, Gee M, Griggs S, Hamilton M, Holley V, Joseph J, Pace P, Palencia J, Satterwhite O, Schmidt J, Volding D, White C, Saad MF, Sengardi SG, Chiu KC, Botrous M, Chan M, Konersman K, Perpetua M, Johnson KC, Gresham C, Connelly S, Brewer A, Coday M, Jones L, Lichtermann L, Vosburg S, Taylor JL, Kitabchi AE, Lambeth H, Clark D, Crisler A, Cunningham G, Green D, Force D, Kores R, Rosenthal R, Smith E, Sun M, Soberman J, Jeffery RW, Thorson C, Bantle JP, Redmon JB, Crow RS, Crow S, Raatz SK, Brelje K, Campbell C, Carls J, Carmean-Mihm T, Finch E, Fox A, Hoelscher E, James LD, Maddy VA, Ockenden T, Rice BI, Skarphol T, Tucker AD, Voeller MS, Walcheck C, Pi-Sunyer X, Patricio J, Heshka S, Pal C, Allen L, Hirsch D, Holowaty MA, Wadden TA, Maschak-Carey BJ, Schwartz S, Foster GD, Berkowitz RI, Glick H, Kumanyika SK, Brock J, Chomentowski H, Clark V, Crerand C, Davenport R, Diamond A, Fabricatore A, Hesson L, Krauthamer-Ewing S, Kuehnel R, Lipschutz P, Mullen M, Womble L, Iqbal N, Kelley DE, Wesche-Thobaben J, Kuller L, Kriska A, Bonk J, Danchenko R, Edmundowicz D, Klem ML, Yamamoto ME, Elnyczky B, Grove GA, Harper P, Krulia J, Mancino J, Mathews A, Murray TY, Ritchea JR, Rush J, Vujevich K, Wolf D, Wing RR, Bright R, Pera V, Jakicic J, Tate D, Gorin A, Gallagher K, Bach A, Bancroft B, Bertorelli A, Carey R, Charron T, Chenot H, Chula-Maguire K, Coward P, Cronkite L, Currin J, Daly M, Egan C, Ferguson E, Foss L, Gauvin J, Kieffer D, Lessard L, Maier D, Massaro JP, Monk T, Nicholson R, Patterson E, Phelan S, Raynor H, Raynor D, Robinson N, Robles D, Tavares J, Haffner SM, Montez MG, Lorenzo C, Kahn S, Montgomery B, Knopp R, Lipkin E, Maciejewski ML, Trence D, Barrett T, Bartell J, Greenberg D, Murillo A, Richmond BA, Thomas A, Knowler WC, Bolin P, Killean T, Manus C, Krakoff J, Curtis JM, Glass J, Michaels S, Bennett PH, Morgan T, Begay S, Fallis B, Hermes J, Hollowbreast DF, Johnson R, Meacham M, Nelson J, Percy C, Poorthunder P, Sangster S, Scurlock N, Shovestull LA, Smiley J, Toledo K, Tomchee C, Tonemah D, Peters A, Ruelas V, Ghazarian Sengardi S, Graves K, Konersman K, Serafin-Dokhan S, Espeland MA, Bahnson JL, Wagenknecht L, Reboussin D, Rejeski WJ, Bertoni A, Lang W, Miller G, Lefkowitz D, Reynolds PS, Ribisl P, Vitolins M, Booth M, Dotson KM, Hodges A, Williams CC, Barnes JM, Feeney PA, Griffin J, Barnes JM, Feeney PA, Griffin J, Harvin L, Herman W, Hogan P, Jaramillo S, King M, Lane K, Neiberg R, Ruggiero A, Speas C, Walkup MP, Wall K, Ward M, West DS, Windham T, Nevitt M, Ewing S, Hayashi C, Maeda J, Palermo L, Rahorst M, Schwartz A, Shepherd J, Marcovina SM, Strylewicz G, Prineas RJ, Alexander T, Billings L, Campbell C, Hall S, Hensley S, Li Y, Zhang ZM, Mayer-Davis EJ, Moran R, Foushee R, Hall NJ, Harrison B, Hubbard VS, Yanovski SZ, Cooper LS, Cutler J, Obarzanek E, Gregg EW, Williamson DF, Zhang P.

Source

Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. Wadden@mail.med.upenn.edu

Abstract

This report provides a further analysis of the first year weight losses in the Look AHEAD (Action for Health in Diabetes) study and identifies factors associated with success. Participants were a total of 5,145 men and women with type 2 diabetes who were recruited at 16 sites and randomly assigned to an intensive lifestyle intervention (ILI) or a control condition, Diabetes Support and Education (DSE). During year 1, participants in ILI received comprehensive diet and physical activity counseling in a total of 42 group and individual sessions, compared with three educational sessions for DSE participants. As reported previously, at the end of the year, ILI participants lost 8.6% of initial weight, compared to 0.7% for DSE (P < 0.001). Within the ILI group, all racial/ethnic groups achieved clinically significant weight losses (>5.5%), although there were significant differences among groups. For the year, ILI participants attended an average of 35.4 treatment sessions and reported exercising a mean of 136.6 min/week and consuming a total of 360.9 meal replacement products. Greater self-reported physical activity was the strongest correlate of weight loss, followed by treatment attendance and consumption of meal replacements. The use of orlistat, during the second half of the year, increased weight loss only marginally in those ILI participants who had lost <5% of initial weight during the first 6 months and chose to take the medication thereafter as a toolbox option. The lifestyle intervention was clinically effective in all subsets of an ethnically and demographically diverse population.