Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Respir Crit Care Med. 2009 May 1;179(9):765-71. doi: 10.1164/rccm.200808-1361OC. Epub 2009 Jan 29.

Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica.

Author information

  • 1Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA.

Abstract

RATIONALE:

Maternal vitamin D intake during pregnancy has been inversely associated with asthma symptoms in early childhood. However, no study has examined the relationship between measured vitamin D levels and markers of asthma severity in childhood.

OBJECTIVES:

To determine the relationship between measured vitamin D levels and both markers of asthma severity and allergy in childhood.

METHODS:

We examined the relation between 25-hydroxyvitamin D levels (the major circulating form of vitamin D) and markers of allergy and asthma severity in a cross-sectional study of 616 Costa Rican children between the ages of 6 and 14 years. Linear, logistic, and negative binomial regressions were used for the univariate and multivariate analyses.

MEASUREMENTS AND MAIN RESULTS:

Of the 616 children with asthma, 175 (28%) had insufficient levels of vitamin D (<30 ng/ml). In multivariate linear regression models, vitamin D levels were significantly and inversely associated with total IgE and eosinophil count. In multivariate logistic regression models, a log(10) unit increase in vitamin D levels was associated with reduced odds of any hospitalization in the previous year (odds ratio [OR], 0.05; 95% confidence interval [CI], 0.004-0.71; P = 0.03), any use of antiinflammatory medications in the previous year (OR, 0.18; 95% CI, 0.05-0.67; P = 0.01), and increased airway responsiveness (a < or =8.58-mumol provocative dose of methacholine producing a 20% fall in baseline FEV(1) [OR, 0.15; 95% CI, 0.024-0.97; P = 0.05]).

CONCLUSIONS:

Our results suggest that vitamin D insufficiency is relatively frequent in an equatorial population of children with asthma. In these children, lower vitamin D levels are associated with increased markers of allergy and asthma severity.

Comment in

PMID:
19179486
[PubMed - indexed for MEDLINE]
PMCID:
PMC2675563
Free PMC Article

Images from this publication.See all images (1)Free text

Figure 1.
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon Icon for PubMed Central
    Loading ...
    Write to the Help Desk