Format

Send to:

Choose Destination
See comment in PubMed Commons below
Endocrinology. 2009 Mar;150(3):1097-107. doi: 10.1210/en.2008-1588. Epub 2009 Jan 29.

Minireview: Defining the roles of the iodothyronine deiodinases: current concepts and challenges.

Author information

  • 1Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA. Donald.L.Stgermain@Dartmouth.edu

Abstract

As is typical of other hormone systems, the actions of the thyroid hormones (TH) differ from tissue to tissue depending upon a number of variables. In addition to varying expression levels of TH receptors and transporters, differing patterns of TH metabolism provide a critical mechanism whereby TH action can be individualized in cells depending on the needs of the organism. The iodothyronine deiodinases constitute a family of selenoenzymes that selectively remove iodide from thyroxine and its derivatives, thus activating or inactivating these hormones. Three deiodinases have been identified, and much has been learned regarding the differing structures, catalytic activities, and expression patterns of these proteins. Because of their differing properties, the deiodinases appear to serve varying functions that are important in regulating metabolic processes, TH action during development, and feedback control of the thyroid axis. This review will briefly assess these functional roles and others proposed for the deiodinases and examine some of the current challenges in expanding our knowledge of these important components of the thyroid homeostatic system.

PMID:
19179439
[PubMed - indexed for MEDLINE]
PMCID:
PMC2654746
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon Icon for PubMed Central
    Loading ...
    Write to the Help Desk