J Am Coll Cardiol. 2009 Feb 3;53(5 Suppl):S9-13.

Lowering glucose to prevent adverse cardiovascular outcomes in a critical care setting.

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Centre of Excellence in Diabetes and Endocrinology, University Hospital of Coventry and Warwickshire, Warwick Medical School, University of Warwick, Coventry, United Kingdom. antonio.ceriello@warwick.ac.uk

Abstract

High admission blood glucose levels after acute myocardial infarction are common and associated with an increased risk of death in patients with or without diabetes. Hyperglycemia is associated with altered myocardial blood flow and energetics and can lead to a pro-oxidative/proinflammatory state. The use of intensive insulin treatment has shown superior benefits in the treatment of hyperglycemia versus glucose-insulin-potassium infusion, particularly in critical care settings.

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J Am Coll Cardiol. 2009 Jul 21;54(4):373-4; author reply 374.

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