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Cerebrovasc Dis. 2009;27(3):247-53. doi: 10.1159/000196823. Epub 2009 Jan 29.

Associations of inflammatory and haemostatic biomarkers with poor outcome in acute ischaemic stroke.

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  • 1Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.



Many inflammatory and haemostatic biomarkers show associations with acute ischaemic stroke outcome, but few studies compare a large range of markers.


We assessed clinical status and 16 biomarkers within 24 h of onset in 180 consecutive acute ischaemic stroke patients.


A total of 94 patients had a poor outcome (dead or dependent at 30 days). C-reactive protein (CRP), IL-6, and fibrin D-dimer showed the strongest univariate associations with poor outcome (>2-fold increase; p < 0.01). When all biomarkers were included with clinical variables in a multivariable model, only D-dimer (OR 1.54; 95% CI 1.09-2.17), CRP (OR 1.31; 95% CI 1.03-1.68) and Scandinavian Stroke Scale (OR 0.91; 95% CI 0.88-0.95) were associated with poor outcome.


D-dimer and CRP are independently associated with poor outcome in acute ischaemic stroke. More data is required to expand our understanding of these potential relationships with outcome.

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