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Development. 2009 Mar;136(5):843-53. doi: 10.1242/dev.027805. Epub 2009 Jan 28.

Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis.

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  • 1Department of Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Integrin receptors for the extracellular matrix and receptor tyrosine kinase growth factor receptors represent two of the major families of receptors that transduce into cells information about the surrounding environment. Wnt proteins are a major family of signaling molecules that regulate morphogenetic events. There is presently little understanding of how the expression of Wnt genes themselves is regulated. In this study, we demonstrate that alpha3beta1 integrin, a major laminin receptor involved in the development of the kidney, and c-Met, the receptor for hepatocyte growth factor, signal coordinately to regulate the expression of Wnt7b in the mouse. Wnt signals in turn appear to regulate epithelial cell survival in the papilla of the developing kidney, allowing for the elongation of epithelial tubules to form a mature papilla. Together, these results demonstrate how signals from integrins and growth factor receptors can be integrated to regulate the expression of an important family of signaling molecules so as to regulate morphogenetic events.

PMID:
19176588
[PubMed - indexed for MEDLINE]
PMCID:
PMC2685949
Free PMC Article

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