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Heart. 2009 May;95(9):704-8. doi: 10.1136/hrt.2008.154054. Epub 2009 Jan 28.

Statin use is associated with lower risk of atrial fibrillation in women with coronary disease: the HERS trial.

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  • 1Division of Cardiology, Electrophysiology Section, University of California, San Francisco, California, USA.

Abstract

OBJECTIVE:

To determine the efficacy of statin treatment in atrial fibrillation (AF) prevention in women.

DESIGN:

Cohort study using data obtained in the Heart and Estrogen/Progestin Replacement Study (HERS).

SETTING:

Secondary analysis of a multicentre, randomised controlled clinical trial.

PATIENTS:

2673 Postmenopausal women with coronary disease.

MAIN OUTCOME MEASURES:

AF prevalence at baseline and incident AF over a mean follow-up of 4.1 years.

RESULTS:

88 Women with AF were identified: 29 at baseline and 59 during follow-up. Women with AF were significantly less likely to be taking a statin at study enrollment than those without AF (22% vs 37%, p = 0.003). Baseline statin use was associated with a 65% lower odds of having AF at baseline after controlling for age, race, history of myocardial infarction or revascularisation and history of heart failure (odds ratio 0.35, 95% confidence interval (CI) 0.13 to 0.93, p = 0.04). The risk of developing AF during the study among those free from AF at baseline, adjusted for the same covariates, was 55% less for those receiving statin treatment (hazard ratio 0.45, 95% CI 0.26 to 0.78, p = 0.004).

CONCLUSIONS:

Statin treatment is associated with a lower prevalence and incidence of AF after adjustment for potential confounders in postmenopausal women with coronary disease.

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PMID:
19176561
[PubMed - indexed for MEDLINE]
PMCID:
PMC3170815
Free PMC Article
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