Biochemistry. 2009 Mar 3;48(8):1675-80.

Selectivity in ligand recognition of G-quadruplex loops.

Campbell NH, Patel M, Tofa AB, Ghosh R, Parkinson GN, Neidle S.

Source

Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.

Abstract

A series of disubstituted acridine ligands have been cocrystallized with a bimolecular DNA G-quadruplex. The ligands have a range of cyclic amino end groups of varying size. The crystal structures show that the diagonal loop in this quadruplex results in a large cavity for these groups, in contrast to the steric constraints imposed by propeller loops in human telomeric quadruplexes. We conclude that the nature of the loop has a significant influence on ligand selectivity for particular quadruplex folds.

PMID:: 19173611; [PubMed - indexed for MEDLINE]

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Cited by 2 PubMed Central articles

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Structures reported by this article

A Bimolecular Anti-Parallel-Stranded Oxytricha Nova Telomeric Quadruplex In Complex With A 3,6-Disubstituted Acridine Bsu-6042 In A Large Unit Cell

PDB: 3EUI

Source: synthetic construct

Method: X-Ray Diffraction

Resolution: 2.2 Å

See all 7 structures...

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