Abstract
A bioassay-guided isolation of an ethanol extract of the fruit of Piper longum L. yielded piperlonguminine, piperine and pipernonaline, as the main antihyperlipidemic constituents. They exhibit appreciable antihyperlipidemic activity in vivo, which is comparable to that of the commercial antihyperlipidemic drug, simvastatin.
Copyright 2009 John Wiley & Sons, Ltd.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / isolation & purification
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Alkaloids / pharmacology*
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Animals
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Benzodioxoles / isolation & purification
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Benzodioxoles / pharmacology*
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Dioxolanes / isolation & purification
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Dioxolanes / pharmacology*
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Fruit / chemistry
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Hypolipidemic Agents / isolation & purification
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Hypolipidemic Agents / pharmacology*
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Male
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Molecular Structure
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Piper / chemistry*
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Piperidines / isolation & purification
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Piperidines / pharmacology*
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Polyunsaturated Alkamides / isolation & purification
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Polyunsaturated Alkamides / pharmacology*
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Rats
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Rats, Wistar
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Simvastatin / pharmacology
Substances
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Alkaloids
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Benzodioxoles
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Dioxolanes
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Hypolipidemic Agents
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Piperidines
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Polyunsaturated Alkamides
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pipernonaline
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Simvastatin
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piperlongumine
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piperine