Antihyperlipidemic compounds from the fruit of Piper longum L

Phytother Res. 2009 Aug;23(8):1194-6. doi: 10.1002/ptr.2630.

Abstract

A bioassay-guided isolation of an ethanol extract of the fruit of Piper longum L. yielded piperlonguminine, piperine and pipernonaline, as the main antihyperlipidemic constituents. They exhibit appreciable antihyperlipidemic activity in vivo, which is comparable to that of the commercial antihyperlipidemic drug, simvastatin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / isolation & purification
  • Alkaloids / pharmacology*
  • Animals
  • Benzodioxoles / isolation & purification
  • Benzodioxoles / pharmacology*
  • Dioxolanes / isolation & purification
  • Dioxolanes / pharmacology*
  • Fruit / chemistry
  • Hypolipidemic Agents / isolation & purification
  • Hypolipidemic Agents / pharmacology*
  • Male
  • Molecular Structure
  • Piper / chemistry*
  • Piperidines / isolation & purification
  • Piperidines / pharmacology*
  • Polyunsaturated Alkamides / isolation & purification
  • Polyunsaturated Alkamides / pharmacology*
  • Rats
  • Rats, Wistar
  • Simvastatin / pharmacology

Substances

  • Alkaloids
  • Benzodioxoles
  • Dioxolanes
  • Hypolipidemic Agents
  • Piperidines
  • Polyunsaturated Alkamides
  • pipernonaline
  • Simvastatin
  • piperlongumine
  • piperine