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J Clin Neuromuscul Dis. 2008 Dec;10(2):42-51. doi: 10.1097/CND.0b013e31818e9510.

Electrodiagnostic and clinical aspects of Guillain-Barré syndrome: an analysis of 142 cases.

Author information

  • 1Department of Neurology and daggerAchutha Menon Centre For Health Science Studies, Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Trivandrum, Kerala, India. dg14_9@rediffmail.com

Erratum in

  • J Clin Neuromuscul Dis. 2009 Mar;10(3):137. Deepak, Gupta [corrected to Gupta, Deepak]; Muraleedharan, Nair [corrected to Nair, Muraleedharan]; Sarma, Sankara P [corrected to Sarma, P Sankara]; Abraham, Kuruvilla [corrected to Kuruvilla, Abraham].

Abstract

BACKGROUND:

The incidence of Guillain-Barré syndrome (GBS) and its subtypes varies throughout the world.

OBJECTIVE AND METHODS:

We present a retrospective analysis of 142 GBS cases, treated at our center, aimed at classifying GBS electrophysiologically, to study the sequential electrophysiological changes in cases with acute inflammatory demyelinating polyradiculoneuropathy (AIDP), and to look for any clinical and cerebrospinal fluid parameters that can also help in distinguishing the subtypes.

RESULTS:

One hundred twenty-one (85.2%) cases had AIDP, 15 (10.6%) had acute motor axonal neuropathy, and 6 (4.2%) were unclassifiable.

CONCLUSIONS:

Motor conduction blocks and temporal dispersion could be observed from days 3 and 5 onward, respectively. Progression of motor conduction slowing in AIDP was most impressive in the median nerves. Varying affection of deep tendon reflexes, cranial nerves, and cerebrospinal fluid albuminocytological dissociation can also help make a distinction between AIDP and acute motor axonal neuropathy. Sural sparing, a marker of demyelinating neuropathy, is more commonly seen in later than in early stages of AIDP.

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