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Immun Infekt. 1991 Jun;19(3):83-6.

[Clinical experiences with mefloquine in tropical malaria--a prospective study].

[Article in German]

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  • 1Universitätsklinikum Rudolf Virchow, Abteilung für Innere Medizin mit Schwerpunkt Infektionskrankheiten, Berlin.


The therapeutic effects and side effects of mefloquine in falciparum malaria were investigated in an open prospective trial involving 20 patients. None of them had a history of neurologic or psychiatric disorders. Mefloquine was given in a total dose of 1500 mg base. The cure rate was 100%, fever and parasitemia subsided within 3 days. Side effects were vomitus and nausea in 25% of the patients. No neurological or psychiatric disorders were observed. Mefloquine was shown to be a safe therapeutic agent in the dosage used. However, regular follow-up examinations should be done in short intervals because of the possibility of late neuropsychiatric side effects; the patients and their relatives should be informed about this fact.

[PubMed - indexed for MEDLINE]
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