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Biochim Biophys Acta. 2009 Apr;1793(4):615-24. doi: 10.1016/j.bbamcr.2008.12.022. Epub 2009 Jan 8.

Delivery of endocytosed membrane proteins to the lysosome.

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  • 1Department of Biology (Area 9), University of York, York, YO10 5YW, UK. pp517@york.ac.uk

Abstract

The delivery of proteins from the plasma membrane to the lysosome for degradation is essential for normal cellular function. There is now a good understanding of the protein complexes involved in sorting proteins at the plasma membrane and into the intralumenal vesicles of the multi-vesicular body. A combination of cell free content mixing assays and live-cell imaging has dissected out the final step in delivery of macromolecules to the lysosome from the multi-vesicular body and provided insights into the molecular mechanisms by which late endosomes and lysosomes exchange lumenal contents. The endocytic pathway has provided a platform with which to understand the autophagic and phagocytic pathways, but the fine details of how traffic through these pathways is regulated remain to be determined.

PMID:
19167432
[PubMed - indexed for MEDLINE]
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