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Nat Genet. 2008 Sep;40(9):1059-61. doi: 10.1038/ng.200.

Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.

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  • 1Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease influenced by genetic and environmental factors. We carried out a genome-wide association scan and replication study and found an association between SLE and a variant in TNFAIP3 (rs5029939, meta-analysis P = 2.89 x 10(-12), OR = 2.29). We also found evidence of two independent signals near TNFAIP3 associated with SLE, including one previously associated with rheumatoid arthritis (RA). These results establish that variants near TNFAIP3 contribute to differential risk of SLE and RA.

PMID:
19165918
[PubMed - indexed for MEDLINE]
PMCID:
PMC2772171
Free PMC Article

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