Fortschr Med. 1991 Jun 20;109(18):385-8.

[Mineral metabolism and aluminum burden with hydrotalcit. A placebo-controlled randomized double-blind study].

[Article in German]

Abstract

In a randomized, double-blind study, the influence of hydrotalcit (aluminium-magnesium hydroxide carbonate hydrate) on the mineral metabolism was investigated. No significant and clinically relevant changes in calcium, phosphate, magnesium or aluminium concentrations in the serum were observed. Nor were these substances eliminated in greater amounts in the urine. Merely the elimination of magnesium was higher in the group receiving the test substance than in the placebo group; after discontinuation of the medication, no difference in the elimination rates was found. Thus, provided that renal function is intact, the use of hydrotalcit does not lead to any disturbance in the mineral balance, or, in particular, to any additional aluminium burden.

PMID:: 1916557; [PubMed - indexed for MEDLINE]

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