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    Fly (Austin). 2009 Jan-Mar;3(1):68-73. Epub 2009 Jan 7.

    Hippo signaling pathway and organ size control.

    Zhang L, Yue T, Jiang J.

    Source

    Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

    Abstract

    Initially discovered in Drosophila, the Hippo (Hpo) pathway has been recognized as a conserved signaling pathway that controls organ size during development by restricting cell growth and proliferation and by promoting apoptosis. In addition, abnormal activities of several Hpo pathway components have been implicated in human cancer. Here, we review the current understanding of the molecular and cellular basis of Hpo signaling in development and tumorigenesis, and discuss how the Hpo pathway integrates spatial and temporal signals to control tissue growth and organ size.

    PMID:
    19164949
    [PubMed - indexed for MEDLINE]
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