Int J Surg Pathol. 2011 Feb;19(1):80-3. Epub 2009 Jan 22.

Xp11.2 translocation renal carcinoma with placental metastasis: a case report.

Bovio IM, Allan RW, Oliai BR, Hampton T, Rush DS.

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Department of Pathology, College of Medicine, University of Florida, Gainesville, Florida, USA. boviim@pathology.ufl.edu

Abstract

Renal cell carcinomas with sporadic Xp11.2 translocations are uncommon malignancies in children and young adults associated with several different reciprocal translocations involving the TFE3 gene located on chromosome Xp11.2. Placental metastases are extremely rare, with only a handful of cases reported. This study reports the case of a 20-year-old woman with an Xp11.2 translocation renal carcinoma that metastasized to the placenta. This is the first reported case of a renal cell carcinoma metastatic to the placenta and highlights the aggressive behavior of Xp11 translocation renal cell carcinomas.

PMID:: 19164407; [PubMed - indexed for MEDLINE]

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Cited by 2 PubMed Central articles

TFE3 Translocation-Associated Renal Cell Carcinoma Presenting as Avascular Necrosis of the Femur in a 19-Year-Old Patient: Case Report and Review of the Literature. [Case Report Med. 2011]
TFE3 Translocation-Associated Renal Cell Carcinoma Presenting as Avascular Necrosis of the Femur in a 19-Year-Old Patient: Case Report and Review of the Literature.
Nelius T, Al-Khalil I, Vordermark J, Rinard-Holden K, Cammack T, Mamlok V, Filleur S. Case Report Med. 2011; 2011:432917. Epub 2011 Oct 5.
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