Evolution and pathogenesis of Leptospira spp.: lessons learned from the genomes

Feng Xue; Jie Yan; Mathieu Picardeau

doi:10.1016/j.micinf.2008.12.007

Evolution and pathogenesis of Leptospira spp.: lessons learned from the genomes

Microbes Infect. 2009 Mar;11(3):328-33. doi: 10.1016/j.micinf.2008.12.007. Epub 2008 Dec 27.

Authors

Feng Xue¹, Jie Yan, Mathieu Picardeau

Affiliation

¹ Division of Basic Medical Microbiology, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital of Medical College, Zhejiang University, 310058 Hangzhou, Zhejiang, PR China. sherlock_hsueh@hotmail.com

PMID: 19159695
DOI: 10.1016/j.micinf.2008.12.007

Abstract

Leptospirosis has emerged to become a major public health problem in developing countries. The availability of complete sequences of strains representing saprophytic and pathogenic species of the genus Leptospira is providing insights into the evolution of virulence and survival mechanisms used by these bacteria to persist in different ecological niches.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Evolution, Molecular*
Genome, Bacterial*
Leptospira / genetics*
Leptospira / pathogenicity*
Virulence Factors / genetics*

Substances

Virulence Factors