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Nature. 2009 Jan 22;457(7228):413-20. doi: 10.1038/nature07756.

Small RNAs in transcriptional gene silencing and genome defence.

Author information

  • Howard Hughes Medical Institute, and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA. danesh_moazed@hms.harvard.edu

Abstract

Small RNA molecules of about 20-30 nucleotides have emerged as powerful regulators of gene expression and genome stability. Studies in fission yeast and multicellular organisms suggest that effector complexes, directed by small RNAs, target nascent chromatin-bound non-coding RNAs and recruit chromatin-modifying complexes. Interactions between small RNAs and nascent non-coding transcripts thus reveal a new mechanism for targeting chromatin-modifying complexes to specific chromosome regions and suggest possibilities for how the resultant chromatin states may be inherited during the process of chromosome duplication.

PMID:
19158787
[PubMed - indexed for MEDLINE]
PMCID:
PMC3246369
Free PMC Article

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