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Obstet Gynecol. 2009 Feb;113(2 Pt 2):484-6. doi: 10.1097/AOG.0b013e318187e795.

Bradycardia and cardiac arrest caused by intramyometrial injection of vasopressin during a laparoscopically assisted myomectomy.

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  • 1Department of Gynecology, Yotsuya Medical Cube, Sanno Hospital, Tokyo, Japan.



Vasopressin is often used locally to reduce blood loss during surgery. The use of a local infiltration of a low concentration of vasopressin, less than 0.05-0.3 units/mL, has been considered to be safe. The use of low-dose vasopressin is not free of side effects, and it can also sometimes cause lethal complications.


In a healthy woman with multiple uterine myomas, we experienced a case of sudden cardiac arrest immediately after the intramyometrial injection of vasopressin at a total dose of 11 units (0.2 units/mL). The patient was successfully resuscitated.


Local intramyometrial infiltration of low-dose vasopressin may cause lethal cardiopulmonary complications.

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