Eur J Pediatr. 1991 Jul;150(9):661-4.

Phenylketonuria does not cause cataracts.

Source

Murdoch Institute, Royal Children's Hospital, Parkville, Melbourne, Australia.

Abstract

In a study of 46 adults aged 28-71 years with untreated phenylketonuria (PKU) there were 3 (6.5%) with cataracts. This incidence was similar to that in the Australian population and in a control series of intellectually disabled adults. Only two of the PKU patients with cataracts could be examined by slit-lamp biomicroscopy and in both the findings suggested that the prolonged use of phenothiazines may have played a role. Slit-lamp examination of a further ten untreated PKU patients and 13 PKU adults who had been treated in childhood revealed only small lens opacities (in 40%) of a type found in 72.7% of a control group. The study provides no support for claims that PKU can cause cataracts.

PMID:: 1915521; [PubMed - indexed for MEDLINE]

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