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Cell Host Microbe. 2009 Jan 22;5(1):6-7. doi: 10.1016/j.chom.2008.12.005.

Cholesterol paves the way for topically applied viricides.

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  • 1Department of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.


Sexually transmitted viral infections have the potential to be prevented and treated by topical viricides. Here, Wu et al. (2009) demonstrate that cholesterol-conjugated small interfering RNAs (siRNAs) targeting a cellular receptor combined with an antiviral siRNA when topically applied to mucosal tissue blocked lethal herpes virus infections in mice.

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