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    Curr Drug Targets. 2009 Jan;10(1):38-41.

    PDGF-D signaling: a novel target in cancer therapy.

    Source

    Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA.

    Abstract

    Platelet-derived growth factor-D (PDGF-D) is a newly recognized growth factor that can regulate many cellular processes, including cell proliferation, transformation, invasion, and angiogenesis by specifically binding to and activating its cognate receptor PDGFR-beta. The functions of PDGF-D in human cancer progression are largely unknown. We discuss here the role of PDGF-D signaling pathway in cancer and how its deregulation is involved in tumor development and progression to metastatic disease.

    PMID:
    19149534
    [PubMed - indexed for MEDLINE]

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