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    The Chiptip: a novel tool for automated patch clamp.

    Source

    Flyion GmbH, Waldhäuserstr. 64, D-72076 Tübingen, Germany. info@flyion.com

    Abstract

    To facilitate automated patch clamp measurements of ion channels in cells, the development of an all-glass Chiptip pipette is reported that may be combined with the previously described Flip-the-Tip technology. A single measurement requires less than 50 cells, and the addition of drugs for screening can be limited to very low volumes down to 1 microL. This apparatus is suitable for the study small cells, subcellular organelles and bacteria.

    PMID:
    19149493
    [PubMed - indexed for MEDLINE]

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