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Genome Biol. 2008;9(12):244. doi: 10.1186/gb-2008-9-12-244. Epub 2008 Dec 30.

Replication forks, chromatin loops and dormant replication origins.

Author information

  • 1Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK. j.j.blow@dundee.ac.uk

Abstract

When DNA replication is slowed down, normally dormant replication origins are activated. Recent work demonstrates that cells adapt by changing the organization of chromatin loops and maintaining the new pattern of origin use in subsequent cell cycles.

PMID:
19144207
[PubMed - indexed for MEDLINE]
PMCID:
PMC2646269
Free PMC Article

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