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ORL J Otorhinolaryngol Relat Spec. 2009;71(2):78-86. doi: 10.1159/000189783. Epub 2009 Jan 10.

Ménière's disease is a viral neuropathy.

Author information

  • Department of Otolaryngology-Head and Neck Surgery, University of Massachusetts Medical School, Worcester, MA 01655, USA. gacekr@ummhc.org

Abstract

Morphological and clinical evidence supports a viral neuropathy in Ménière's disease (MD). Quantitative examination of 11 sectioned temporal bones (TBs) from 8 patients with a history of MD revealed a significant loss of vestibular ganglion cells in both the endolymph hydropic (EH) and non-EH ears. Transmission electron microscopy of vestibular ganglion cells excised from a patient with MD revealed viral particles enclosed in transport vesicles. Antiviral treatment controlled vertigo in 73 of 86 patients with vestibular neuronitis (85%) and 32 of 35 patients with MD (91%).

Copyright 2009 S. Karger AG, Basel.

PMID:
19142031
[PubMed - indexed for MEDLINE]
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