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Genes Dev. 2008 Dec 15;22(24):3375-82. doi: 10.1101/gad.1759708.

Talk is cheap--cross-talk in establishment, maintenance, and readout of chromatin modifications.

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  • 1Laboratory of Chromatin Biochemistry, Max-Planck Institute for Biophysical Chemistry, D-37077 Göttingen, Germany.


The functionality of a cell's genome is controlled epigenetically on the level of chromatin. Multiple post-translational modifications of histone proteins together with DNA methylation play a key role in directing distinct functional states of chromatin. As it emerges, many epigenetic marks on the chromatin platform do not act independently, but cross-talk with each other. In this issue of Genes & Development, Adhvaryu and Selker (3391-3396) provide novel insights into an intricate regulatory network involving histone phosphorylation, histone methylation, and DNA methylation.

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