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Clin Infect Dis. 2009 Feb 15;48(4):484-8. doi: 10.1086/596482.

Better adherence with once-daily antiretroviral regimens: a meta-analysis.

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  • 1Department of Biostatistics and Clinical Research, Côte de Nacre University Hospital, Caen, France.


Once-daily regimens of antiretroviral therapy are simpler than other regimens, but whether such regimens are associated with better adherence to treatment is controversial. We performed a meta-analysis of 11 randomized, controlled trials (total number of subjects, 3029), which revealed that the adherence rate was better with once-daily regimens (+2.9%; 95% confidence interval, 1.0%-4.8%; P < .003) than with twice-daily regimens. This modest effect was more pronounced at the time of treatment initiation and for regimens for which all medications were taken once per day.

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