Adv Drug Deliv Rev. 2009 Feb 27;61(2):128-39. Epub 2008 Dec 24.

Gene transfer to the lung: lessons learned from more than 2 decades of CF gene therapy.

Griesenbach U, Alton EW; UK Cystic Fibrosis Gene Therapy Consortium.

Source

Department of Gene Therapy, Faculty of Medicine at the National Heart and Lung Institute, Imperial College London, Manresa Road, London SW36LR, UK. u.griesenbach@imperial.ac.uk

Abstract

Gene therapy is currently being developed for a wide range of acute and chronic lung diseases. The target cells, and to a degree the extra and intra-cellular barriers, are disease-specific and over the past decade the gene therapy community has recognized that no one vector is good for all applications, but that the gene transfer agent (GTA) has to be carefully matched to the specific disease target. Gene therapy is particularly attractive for diseases that currently do not have satisfactory treatment options and probably easier for monogenic disorders than for complex diseases. Cystic fibrosis (CF) fulfils these criteria and is, therefore, a good candidate for gene therapy-based treatment. This review will focus on CF as an example for lung gene therapy, but lessons learned may be applicable to other target diseases.

PMID:: 19138713; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

Expectorants

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Supplemental Content

Related citations

Review Gene therapy for cystic fibrosis: an example for lung gene therapy. [Gene Ther. 2004]
Review Gene therapy for cystic fibrosis: an example for lung gene therapy.
Griesenbach U, Geddes DM, Alton EW. Gene Ther. 2004 Oct; 11 Suppl 1:S43-50.
Review Physical and biological barriers to viral vector-mediated delivery of genes to the airway epithelium. [Proc Am Thorac Soc. 2004]
Review Physical and biological barriers to viral vector-mediated delivery of genes to the airway epithelium.
Pickles RJ. Proc Am Thorac Soc. 2004; 1(4):302-8.
Review Gene therapy progress and prospects: cystic fibrosis. [Gene Ther. 2006]
Review Gene therapy progress and prospects: cystic fibrosis.
Griesenbach U, Geddes DM, Alton EW. Gene Ther. 2006 Jul; 13(14):1061-7.
Review Gene therapy for cystic fibrosis by means of aerosol. [J Aerosol Med. 2002]
Review Gene therapy for cystic fibrosis by means of aerosol.
Rochat T, Morris MA. J Aerosol Med. 2002 Summer; 15(2):229-35.
Review Update on gene therapy for cystic fibrosis. [Curr Opin Mol Ther. 2003]
Review Update on gene therapy for cystic fibrosis.
Griesenbach U, Geddes DM, Alton EW. Curr Opin Mol Ther. 2003 Oct; 5(5):489-94.

See reviews... See all...

Cited by 8 PubMed Central articles

Improvement of adenoviral vector-mediated gene transfer to airway epithelia by folate-modified anionic liposomes. [Int J Nanomedicine. 2011]
Improvement of adenoviral vector-mediated gene transfer to airway epithelia by folate-modified anionic liposomes.
Zhong Z, Wan Y, Han J, Shi S, Zhang Z, Sun X. Int J Nanomedicine. 2011; 6:1083-93. Epub 2011 May 25.
Rapid transport of muco-inert nanoparticles in cystic fibrosis sputum treated with N-acetyl cysteine. [Nanomedicine (Lond). 2011]
Rapid transport of muco-inert nanoparticles in cystic fibrosis sputum treated with N-acetyl cysteine.
Suk JS, Lai SK, Boylan NJ, Dawson MR, Boyle MP, Hanes J. Nanomedicine (Lond). 2011 Feb; 6(2):365-75.
Sensitivity of chloride efflux vs. transepithelial measurements in mixed CF and normal airway epithelial cell populations. [Cell Physiol Biochem. 2010]
Sensitivity of chloride efflux vs. transepithelial measurements in mixed CF and normal airway epithelial cell populations.
Illek B, Lei D, Fischer H, Gruenert DC. Cell Physiol Biochem. 2010; 26(6):983-90. Epub 2011 Jan 4.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Gene transfer to the lung: lessons learned from more than 2 decades of CF gene t...
Gene transfer to the lung: lessons learned from more than 2 decades of CF gene therapy.
Adv Drug Deliv Rev. 2009 Feb 27 ;61(2):128-39. Epub 2008 Dec 24 .

PubMed
Increased impulsivity associated with severity of suicide attempt history in pat...
Increased impulsivity associated with severity of suicide attempt history in patients with bipolar disorder.
Am J Psychiatry. 2005 Sep ;162(9):1680-7.

PubMed
Values for macular perimetry using the MP-1 microperimeter in normal subjects.
Values for macular perimetry using the MP-1 microperimeter in normal subjects.
Ophthalmic Res. 2009 ;41(1):9-13. Epub 2008 Oct 13 .

PubMed
Role of alanyl aminopeptidase in growth and function of human T cells (review).
Role of alanyl aminopeptidase in growth and function of human T cells (review).
Int J Mol Med. 1999 Jul ;4(1):17-27.

PubMed
The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop.
The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop.
Cancer Cell. 2007 Oct ;12(4):342-54.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: