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Genome Biol. 2008;9(12):243. doi: 10.1186/gb-2008-9-12-243. Epub 2008 Dec 29.

Lymphatic endothelial differentiation: start out with Sox--carry on with Prox.

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  • 1Max-Planck-Institute for Molecular Biomedicine, Department of Vascular Cell Biology, D-48149 M√ľnster, Germany.


The transcription factor Prox1 is the master regulator of lymphatic endothelial cell differentiation and its expression initiates the morphogenesis of the lymphatic vasculature in the early embryo. Two new studies now answer some fundamental questions concerning Prox1 biology.

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