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Chem Commun (Camb). 2009 Jan 28;(4):407-9. doi: 10.1039/b815888f. Epub 2008 Nov 5.

3-Mercaptopropionic acid-mediated synthesis of peptide and protein thioesters.

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  • 1Department of Chemistry, University College London, 20 Gordon Street, London, UK.

Abstract

Peptides and proteins fragment sequence-specifically in the presence of 3-mercaptopropionic acid to afford thioesters which can be used in native chemical ligation reactions.

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