Clin Biochem. 2009 Mar;42(4-5):400-7. Epub 2008 Dec 24.

Important roles of glycosylphosphatidylinositol (GPI)-specific phospholipase D and some GPI-anchored proteins in the pathogenesis of hepatocellular carcinoma.

Tang JH, He WJ, Huang H, Tan CC, Duan Q, Wang KJ, Yuan XY, Zhu XJ.

Source

Department of Biochemistry, School of Biological Sciences and Technology, Central South University, 172 Tong Zi Po Road, Changsha, Hunan 410013, PR China. miket561@xysm.net

Abstract

OBJECTIVE:

To investigate the roles of glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) in the pathogenesis of hepatocellular carcinoma (HCC).

METHODS:

The expression of the GPI-PLD in HCC was determined. The GPI-PLD gene was stably transfected in HepG2 cells and the proliferation of these cells was detected; CD55, CD59 and apoptotic cells were also analyzed.

RESULTS:

The serum GPI-PLD activities, the protein and mRNA levels of GPI-PLD in HCC patients were decreased by 40%, 60% and 56%, respectively. The killing rate of CDC against the positive clone cells was significantly increased, but the proliferative capacity was obviously decreased. The apoptotic rate in positive clones was increased.

CONCLUSION:

The expression of GPI-PLD decreases in HCC patients. The over-expression of GPI-PLD in HepG2 cells increases their sensitivity to CDC killing, impairs proliferative capacity and promotes apoptosis.

PMID:: 19135435; [PubMed - indexed for MEDLINE]

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