Virology. 2009 Feb 20;384(2):260-5. Epub 2009 Jan 8.

Papillomaviruses in the causation of human cancers - a brief historical account.

Source

Deutsches Krebsforschungszentrum, Heidelberg, Germany. zurhausen@dkfz-heidelberg.de

Abstract

Approximately 35 years ago a role of human papillomaviruses (HPV) in cervical cancer has been postulated. Today it is well established that this very heterogeneous virus family harbours important human carcinogens, causing not only the vast majority of cervical, but also a substantial proportion of other anogenital and head and neck cancers. In addition, specific types have been linked to certain cutaneous cancers. In females, HPV infections on a global scale account for more than 50% of infection-linked cancers, in males for barely 5%. Vaccines against the high risk HPV types 16 and 18 represent the first preventive vaccines directly developed to protect against a major human cancer (cervical carcinoma). This review will cover some of the historical aspects of papillomavirus research; it tries briefly to analyze the present state of linking HPV to human cancers and will discuss some emerging developments.

PMID:: 19135222; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Supplemental Content

Save items

Related citations in PubMed

Review Papillomaviruses in human cancers. [Proc Assoc Am Physicians. 1999]
Review Papillomaviruses in human cancers.
zur Hausen H. Proc Assoc Am Physicians. 1999 Nov-Dec; 111(6):581-7.
Review Chapter 1: HPV in the etiology of human cancer. [Vaccine. 2006]
Review Chapter 1: HPV in the etiology of human cancer.
Muñoz N, Castellsagué X, de González AB, Gissmann L. Vaccine. 2006 Aug 31; 24 Suppl 3:S3/1-10. Epub 2006 Jun 23.
Review Human papillomavirus in cervical and head-and-neck cancer. [Nat Clin Pract Oncol. 2008]
Review Human papillomavirus in cervical and head-and-neck cancer.
Psyrri A, DiMaio D. Nat Clin Pract Oncol. 2008 Jan; 5(1):24-31.
Review [HPV and skin neoplasia]. [Hautarzt. 2008]
Review [HPV and skin neoplasia].
Pfister H. Hautarzt. 2008 Jan; 59(1):26-30.
Review [Papillomaviruses and genital cancer: the value of detection and eradication]. [Prog Urol. 1994]
Review [Papillomaviruses and genital cancer: the value of detection and eradication].
Libert MH. Prog Urol. 1994 Aug-Sep; 4(4):491-8.

See reviews... See all...

Cited by 47 PubMed Central articles

Interferon-β Induces Cellular Senescence in Cutaneous Human Papilloma Virus-Transformed Human Keratinocytes by Affecting p53 Transactivating Activity. [PLoS One. 2012]
Interferon-β Induces Cellular Senescence in Cutaneous Human Papilloma Virus-Transformed Human Keratinocytes by Affecting p53 Transactivating Activity.
Chiantore MV, Vannucchi S, Accardi R, Tommasino M, Percario ZA, Vaccari G, Affabris E, Fiorucci G, Romeo G. PLoS One. 2012; 7(5):e36909. Epub 2012 May 16.
Productive infection of bovine papillomavirus type 2 in the placenta of pregnant cows affected with urinary bladder tumors. [PLoS One. 2012]
Productive infection of bovine papillomavirus type 2 in the placenta of pregnant cows affected with urinary bladder tumors.
Roperto S, Borzacchiello G, Esposito I, Riccardi M, Urraro C, Lucà R, Corteggio A, Tatè R, Cermola M, Paciello O, et al. PLoS One. 2012; 7(3):e33569. Epub 2012 Mar 27.
Nuclear expression of Rac1 in cervical premalignant lesions and cervical cancer cells. [BMC Cancer. 2012]
Nuclear expression of Rac1 in cervical premalignant lesions and cervical cancer cells.
Mendoza-Catalán MA, Cristóbal-Mondragón GR, Adame-Gómez J, Del Valle-Flores HN, Coppe JF, Sierra-López L, Romero-Hernández MA, Del Carmen Alarcón-Romero L, Illades-Aguiar B, Castañeda-Saucedo E. BMC Cancer. 2012 Mar 23; 12:116. Epub 2012 Mar 23.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Papillomaviruses in the causation of human cancers - a brief historical account.
Papillomaviruses in the causation of human cancers - a brief historical account.
Virology. 2009 Feb 20 ;384(2):260-5. Epub 2009 Jan 8 .

PubMed
Malignant transformation of aneurysmal bone cyst, with an analysis of the litera...
Malignant transformation of aneurysmal bone cyst, with an analysis of the literature.
Cancer. 1991 Oct 15 ;68(8):1770-80.

PubMed
Differential responses in CBF and CBV to cocaine as measured by fMRI: implicatio...
Differential responses in CBF and CBV to cocaine as measured by fMRI: implications for pharmacological MRI signals derived oxygen metabolism assessment.
J Psychiatr Res. 2009 Aug ;43(12):1018-24. Epub 2009 Jan 8 .

PubMed
Exsanguination in trauma: A review of diagnostics and treatment options.
Exsanguination in trauma: A review of diagnostics and treatment options.
Injury. 2009 Jan ;40(1):11-20. Epub 2009 Jan 8 .

PubMed
Maternal exposure to ambient air pollutants and risk of congenital anomalies.
Maternal exposure to ambient air pollutants and risk of congenital anomalies.
Environ Res. 2009 Feb ;109(2):181-7. Epub 2009 Jan 8 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: