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Bioconjug Chem. 2009 Feb;20(2):209-12. doi: 10.1021/bc800480k.

PNIPAM gel-coated gold nanorods for targeted delivery responding to a near-infrared laser.

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  • 1Department of Applied Chemistry, Faculty of Engineering, and Center for Future Chemistry, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka 819-0395, Japan.


Gold nanorods can be used as photothermal converters, permitting near-infrared (NIR) light to be transmitted deep into tissues without causing damage. We prepared hybrid nanorods with a core-shell structure, i.e., a single gold nanorod encapsulated in a poly (N-isopropylacrylamide) nanogel. Hybrid nanorods demonstrated remote, reversible, pulsatile phase transition and in vivo action after irradiation using a NIR laser.

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