Nat Rev Cancer. 2009 Feb;9(2):128-34. Epub 2008 Dec 29.

Do 'basal-like' breast cancers really exist?

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Division of Cancer Sciences and Molecular Pathology, University of Glasgow, Western Infirmary (Pathology), Dumbarton Road, Glasgow G11 6NT, Scotland, UK. B.A.Gusterson@clinmed.gla.ac.uk

Abstract

It has been proposed that gene expression profiles will revolutionize the classification of breast cancer, eventually replacing histopathology with a more reproducible technology. These new approaches, combined with a better understanding of the cellular origins of breast cancer, should enable us to identify patient subgroups for more effective therapy. However, in such a rapidly advancing field it is essential that initial and thought-provoking results do not become established as 'facts' without question. This Opinion addresses some of the negatives and positives generated by the term 'basal-like' breast cancer, and questions its existence as an entity.

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