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Angew Chem Int Ed Engl. 2009;48(13):2308-12. doi: 10.1002/anie.200805279.

Oxidase-like activity of polymer-coated cerium oxide nanoparticles.

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  • 1Nanoscience Technology Center, Department of Chemistry and Burnett College of Biomedical Sciences, University of Central Florida, 12424 Research Parkway, Suite 400, Orlando, FL 32826, USA.

Abstract

Inorganic enzyme? Ceria nanoparticles exhibit unique oxidase-like activity at acidic pH values. These redox catalysts can be used in immunoassays (ELISA) when modified with targeting ligands (see picture; light blue and yellow structures are nanoparticles with attached ligands). This modification allows both for binding and for detection by the catalytic oxidation of sensitive colorimetric dyes (e.g. TMB).

PMID:
19130532
[PubMed - indexed for MEDLINE]
PMCID:
PMC2923475
Free PMC Article

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