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    Psychiatr Genet. 2009 Feb;19(1):1-5.

    Positive association of neuroligin-4 gene with nonspecific mental retardation in the Qinba Mountains Region of China.

    Qi H, Xing L, Zhang K, Gao X, Zheng Z, Huang S, Guo Y, Zhang F.

    Source

    College of Life Science, Institute of Population and Health, Northwest University, Xi'an, China.

    Abstract

    OBJECTIVE:

    Neuroligin-4 is essential for proper brain function. Some studies indicate a close relationship between neuroligin-4 and several human psychiatric conditions.

    METHODS:

    The case-control method was used to study the association between nonspecific mental retardation (NSMR) and genetic variants of neuroligin-4 gene (NLGN4). Five single nucleotide polymorphisms (SNPs: rs5916271, rs7049300, rs6638575, rs3810686, and rs1882260) were genotyped by PCR-RFLP/SSCP method in the NLGN4.

    RESULTS:

    Individual SNP analysis shows significant differences at SNPs rs3810686 and rs1882260 for allele frequency when NSMR cases and controls [odds ratio (OR)=1.589, 95% confidence interval (CI)=1.035-2.438, chi2=4.53, df=1, P=0.033; OR=2.050, 95% CI=1.211-3.470, chi2=7.38, df=1, P=0.007, respectively] were compared. Further haplotype analysis indicates that there are two haplotype sets, rs3810686-rs1882260 and rs6638575-rs3810686-rs1882260, which show statistical differences between NSMR cases and controls (chi2=6.79, df=2, global P=0.034; chi2=9.29, df=2, global P=0.0096, respectively).

    CONCLUSION:

    The results suggest a positive association between the genetic variants of the NLGN4 and NSMR in the Chinese children from Qinba Mountains Region.

    PMID:
    19125102
    [PubMed - indexed for MEDLINE]

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