Association signals and recombination rates for loci demonstrating genome-wide significant association with UC on chromosomes a) 1p36, b) 1p31, c) 6p21 and d) 12q15. The vertical axis scale on the left side of each plot represents the –log10 of the P values. The vertical axis scale on the right side of each plot represents the recombination rate in cM/Mb. The UC GWAS –log10 GEM P values are plotted as small diamonds (all arrays shared SNPs GEM dataset, see Supplementary Table 1 online) and small circles (HumanHap550 only SNPs GEM dataset, see Supplementary Table 1 online). Linkage disequilibrium (r²) in the GWAS control data to the single most significantly associated regional SNP is color-coded (red: r² greater than 0.8; orange: r² 0.5−0.8; yellow: r² 0.2−0.5; white: r² less than 0.2). Large blue diamonds with corresponding rs number and P value labels represent combined UC GWAS and replication case-control significance estimates. Light blue lines represent the recombination rates. Conditional analyses (see Supplementary Table 3 online) of replicated markers (large blue diamonds) suggest the presence of independent association signals on chromosome 1p36 and on chromosome 12q15 separated by recombination hotspots.