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Am J Obstet Gynecol. 2009 Jan;200(1):104.e1-11. doi: 10.1016/j.ajog.2008.08.032.

Term labor is associated with a core inflammatory response in human fetal membranes, myometrium, and cervix.

Author information

  • 1Division of Reproductive and Maternal Medicine, Faculty of Medicine, University of Glasgow, Glasgow, Scotland.

Erratum in

  • Am J Obstet Gynecol. 2009 Aug;201(2):214. Bollopragada, Shrikant [corrected to Bollapragada, Shrikant].

Abstract

OBJECTIVE:

Identify overlap of the transcriptome of myometrium and cervix in association with human labor.

STUDY DESIGN:

The transcriptional profile of myometrial and cervical biopsies obtained from women in spontaneous labor at term (n = 9) and not in labor (n = 9) were characterized by Affymetrix v2 U133 plus 2 arrays. Common canonical pathways and functional groups were identified by Ingenuity Pathway Analysis.

RESULTS:

One hundred ten genes (false discovery rate < 1%) were commonly up-regulated by myometrium and cervix in association with labor and 29 genes (false discovery rate < 1%) down-regulated. Fold change in expression of up-regulated genes was strongly correlated; myometrium vs cervix (r = 0.51; P < .001), with no relationship in down-regulated genes (r = 0.26; P = .16). Canonical pathway analysis established up-regulation of inflammatory pathway signaling, with greatest increases in cellular movement and immune response gene ontology groups.

CONCLUSION:

Gestational tissues exhibit a core inflammatory response in association with human parturition, with pathways regulating cellular trafficking dominating.

PMID:
19121663
[PubMed - indexed for MEDLINE]
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