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    Cytokine. 2009 Feb;45(2):58-69. Epub 2009 Jan 1.

    miRNA regulation of cytokine genes.

    Asirvatham AJ, Magner WJ, Tomasi TB.

    Source

    Roswell Park Cancer Institute, Laboratory of Molecular Medicine, Department of Immunology, Elm & Carlton Streets, Buffalo, NY 14263, USA.

    Abstract

    In this review we discuss specific examples of regulation of cytokine genes and focus on a new mechanism involving post-transcriptional regulation via miRNAs. The post-transcriptional regulation of cytokine genes via the destabilizing activity of AU-rich elements [AREs] and miRNAs is a pre-requisite for regulating the half-life of many cytokines and achieving the temporal and spatial distributions required for regulation of these genes.

    PMID:
    19121586
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC3129852
    Free PMC Article

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