Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Diagn Pathol. 2009 Jan 2;4:1. doi: 10.1186/1746-1596-4-1.

Antinuclear antibodies and their detection methods in diagnosis of connective tissue diseases: a journey revisited.

Author information

  • 1Department of Pathology and Laboratory Medicine, Grecian Superspeciality, Heart, Cancer and Multispeciality Hospital, Sector 69, Mohali, India. yashwantk74@yahoo.com

Abstract

It has been more than 50 years since antinuclear antibodies were first discovered and found to be associated with connective tissue diseases. Since then different methods have been described and used for their detection or confirmation. For many decades immunofluorescent antinuclear antibody test has been the "gold standard" in the diagnosis of these disorders. However to increase the sensitivity and specificity of antinuclear antibody detection further approaches were explored. Today a battery of newer techniques are available some of which are now considered better and are competing with the older methods. This article provides an overview on advancement in antinuclear antibody detection methods, their future prospects, advantages, disadvantages and guidelines for use of these tests.

PMID:
19121207
[PubMed]
PMCID:
PMC2628865
Free PMC Article

Images from this publication.See all images (2)Free text

Figure 1
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Write to the Help Desk