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Vet Anaesth Analg. 2009 Jan;36(1):67-76. doi: 10.1111/j.1467-2995.2008.00422.x.

A comparison of epidural buprenorphine plus detomidine with morphine plus detomidine in horses undergoing bilateral stifle arthroscopy.

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  • 1Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA. bfischer@vetspecialty.com

Abstract

OBJECTIVE:

To compare the analgesic efficacy of buprenorphine plus detomidine with that of morphine plus detomidine when administered epidurally in horses undergoing bilateral stifle arthroscopy.

STUDY DESIGN:

Prospective, randomized, blinded clinical trial.

ANIMALS:

Twelve healthy adult horses participating in an orthopedic research study. Group M (n = 6) received morphine (0.2 mg kg(-1)) and detomidine (0.15 mg kg(-1)) epidurally; group B (n = 6) received buprenorphine (0.005 mg kg(-1)) and detomidine (0.15 mg kg(-1)) epidurally.

METHODS:

Horses received one of two epidural treatments following induction of general anesthesia for bilateral stifle arthroscopy. Heart rate (HR), mean arterial blood pressure (MAP), end-tidal CO(2) (Pe'CO(2)), and end-tidal isoflurane concentrations (E'Iso%) were recorded every 15 minutes following epidural administration. Post-operative assessment was performed at 1, 2, 3, 6, 9, 12, and 24 hours after standing; variables recorded included HR, respiratory rate (f(R)), abdominal borborygmi, defecation, and the presence of undesirable side effects. At the same times post-operatively, each horse was videotaped at a walk and subsequently assigned a lameness score (0-4) by three ACVS diplomates blinded to treatment and who followed previously published guidelines. Nonparametric data were analyzed using Wilcoxon's rank-sum test. Inter- and intra-rater agreement were determined using weighted kappa coefficients. Statistical significance was set at p <or= 0.05.

RESULTS:

No statistically significant differences were found between groups with respect to intra-operative HR, MAP, E'Iso%, or post-operative HR, gastrointestinal function and cumulative median lameness scores. Post-operative f(R) in group B [24 (12-30), median (range)] breaths per minute was significantly higher than in group M [18 (15-20)] breaths per minute, p = 0.04.

CONCLUSIONS AND CLINICAL RELEVANCE:

In horses undergoing bilateral stifle arthroscopy, these doses of buprenorphine plus detomidine injected epidurally produced analgesia similar in intensity and duration to that of morphine plus detomidine injected epidurally.

[PubMed - indexed for MEDLINE]
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