Warning: The NCBI web site requires JavaScript to function. more...

My NCBI Sign In

Result Filters

Ann N Y Acad Sci. 2008 Dec;1150:112-22.

Closing the circle between the bedside and the bench: Toll-like receptors in models of virally induced diabetes.

Bortell R, Pino SC, Greiner DL, Zipris D, Rossini AA.

Source

Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA. rita.bortell@umassmed.edu

Abstract

Animal models provide many strategies to unravel the complex interplay of genetic, immunologic, and environmental factors involved in the pathogenesis of type 1A (autoimmune) diabetes. Diabetes can be studied at multiple levels, and new technological advancements provide insights into the functioning of organelle and cellular structures. The role of innate immunity in the response to environmental pathogens has provided possible biochemical and molecular mechanisms which can explain certain clinical events in diabetes. These investigations may uncover new therapies and strategies to prevent type 1A diabetes.

PMID:: 19120279; [PubMed - indexed for MEDLINE]
PMCID:: PMC2625298

Free PMC Article

Images from this publication.See all images (2) Free text

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Toll-Like Receptors

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Viral Infections - MedlinePlus Health Information

Supplemental Content

Icon for Blackwell Publishing

Icon for PubMed Central

Save items

loading

Related citations in PubMed

Review [Viruses as the etiological factor of type 1 diabetes. Animal models]. [Ukr Biokhim Zh. 2005]
Review [Viruses as the etiological factor of type 1 diabetes. Animal models].
Kuchmerovskaia TM, Karpov AV, Donchenko GV. Ukr Biokhim Zh. 2005 Jan-Feb; 77(1):32-40.
Innate immune pathways in virus-induced autoimmune diabetes. [Ann N Y Acad Sci. 2008]
Innate immune pathways in virus-induced autoimmune diabetes.
Nair A, Wolter TR, Meyers AJ, Zipris D. Ann N Y Acad Sci. 2008 Dec; 1150:139-42.
Review The role of innate immune pathways in type 1 diabetes pathogenesis. [Curr Opin Endocrinol Diabetes ...]
Review The role of innate immune pathways in type 1 diabetes pathogenesis.
Pino SC, Kruger AJ, Bortell R. Curr Opin Endocrinol Diabetes Obes. 2010 Apr; 17(2):126-30.
Review Innate immunity and its role in type 1 diabetes. [Curr Opin Endocrinol Diabetes ...]
Review Innate immunity and its role in type 1 diabetes.
Zipris D. Curr Opin Endocrinol Diabetes Obes. 2008 Aug; 15(4):326-31.
Review The role of Toll-like receptor pathways in the mechanism of type 1 diabetes. [Curr Mol Med. 2009]
Review The role of Toll-like receptor pathways in the mechanism of type 1 diabetes.
Lien E, Zipris D. Curr Mol Med. 2009 Feb; 9(1):52-68.

See reviews... See all...

Cited by 1 PubMed Central article

Review The role of innate immune pathways in type 1 diabetes pathogenesis. [Curr Opin Endocrinol Diabetes ...]
Review The role of innate immune pathways in type 1 diabetes pathogenesis.
Pino SC, Kruger AJ, Bortell R. Curr Opin Endocrinol Diabetes Obes. 2010 Apr; 17(2):126-30.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Closing the circle between the bedside and the bench: Toll-like receptors in mod...
Closing the circle between the bedside and the bench: Toll-like receptors in models of virally induced diabetes.
Ann N Y Acad Sci. 2008 Dec ;1150:112-22.

PubMed
Zoonoses and climate variability.
Zoonoses and climate variability.
Ann N Y Acad Sci. 2008 Dec ;1149:326-30.

PubMed
Effects of MAOA-genotype, alcohol consumption, and aging on violent behavior.
Effects of MAOA-genotype, alcohol consumption, and aging on violent behavior.
Alcohol Clin Exp Res. 2009 Mar ;33(3):428-34. Epub 2008 Dec 13 .

PubMed
Pathological dissociation and neuropsychological functioning in borderline perso...
Pathological dissociation and neuropsychological functioning in borderline personality disorder.
Acta Psychiatr Scand. 2009 May ;119(5):383-92. Epub 2008 Dec 22 .

PubMed
[Problem of the multiple-connected regulation of respiratory indices (pH, pO2, p...
[Problem of the multiple-connected regulation of respiratory indices (pH, pO2, pCO2) of the body].
Usp Fiziol Nauk. 1975 Oct-Dec ;6(4):34-64.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...

You are here: NCBI > Literature > PubMed

Write to the Help Desk