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Ann N Y Acad Sci. 2008 Dec;1150:112-22. doi: 10.1196/annals.1447.025.

Closing the circle between the bedside and the bench: Toll-like receptors in models of virally induced diabetes.

Author information

  • 1Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA. rita.bortell@umassmed.edu

Abstract

Animal models provide many strategies to unravel the complex interplay of genetic, immunologic, and environmental factors involved in the pathogenesis of type 1A (autoimmune) diabetes. Diabetes can be studied at multiple levels, and new technological advancements provide insights into the functioning of organelle and cellular structures. The role of innate immunity in the response to environmental pathogens has provided possible biochemical and molecular mechanisms which can explain certain clinical events in diabetes. These investigations may uncover new therapies and strategies to prevent type 1A diabetes.

PMID:
19120279
[PubMed - indexed for MEDLINE]
PMCID:
PMC2625298
Free PMC Article

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