Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Curr Top Dev Biol. 2008;83:41-64. doi: 10.1016/S0070-2153(08)00402-X.

Sex determination in the Caenorhabditis elegans germ line.

Author information

  • Department of Molecular Biology, School of Osteopathic Medicine, B303 Science Center, The University of Medicine and Dentistry of New Jersey, Stratford, NJ 08084, USA.


Sexual identity is one of the most important factors that determine how an animal will develop. Although it controls many dimorphic tissues in the body, its most ancient role is in the germ line, where it species that some cells become sperm, and others become eggs. In most animals, these two fates occur in distinct sexes. However, certain nematodes like C. elegans produce XX hermaphrodites, which make both types of gametes. In these animals, a core sex-determination pathway regulates the development of both the body and the germ line. However, modifier genes alter the activity of this pathway in germ cells, and these changes are critical for allowing XX animals to produce oocytes and sperm in an otherwise female body. In this review, I focus on (1) the core sex-determination pathway, (2) the activity of the transcription factor TRA-1 and its immediate targets fog-1 and fog-3 in germ cells, (3) how the regulation of tra-2 activity allows XX spermatogenesis, and (4) how the regulation of fem-3 activity maintains the appropriate balance between TRA-2 and FEM-3 in the germ line. Finally, I consider the major questions in this field that are driving new research.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk