Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Cell Sci. 2009 Jan 15;122(Pt 2):199-206. doi: 10.1242/jcs.018564.

Integrins in cell migration--the actin connection.

Author information

  • 1Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. mvicente@virginia.edu

Erratum in

  • J Cell Sci. 2009 May 1;122(Pt 9):1473.

Abstract

The connection between integrins and actin is driving the field of cell migration in new directions. Integrins and actin are coupled through a physical linkage, which provides traction for migration. Recent studies show the importance of this linkage in regulating adhesion organization and development. Actin polymerization orchestrates adhesion assembly near the leading edge of a migrating cell, and the dynamic cross-linking of actin filaments promotes adhesion maturation. Breaking the linkage between actin and integrins leads to adhesion disassembly. Recent quantitative studies have revealed points of slippage in the linkage between actin and integrins, showing that it is not always efficient. Regulation of the assembly and organization of adhesions and their linkage to actin relies on signaling pathways that converge on components that control actin polymerization and organization.

PMID:
19118212
[PubMed - indexed for MEDLINE]
PMCID:
PMC2714416
Free PMC Article

Images from this publication.See all images (4)Free text

Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk