Injury. 2009 Jan;40(1):21-7. Epub 2008 Dec 30.

The role of erythropoietin in the acute phase of trauma management: evidence today.

Kanakaris NK, Petsatodis G, Chalidis B, Manidakis N, Kontakis G, Giannoudis PV.

Source

Academic Department of Trauma & Orthopaedics, Leeds Teaching Hospitals, Leeds, UK.

Abstract

Trauma patients often present in a state of haemorrhagic shock. Blood products remain the gold standard of resuscitation, but allogeneic blood transfusions (ABTs) are associated with several risks. The stimulating effect of recombinant-erythropoietin (EPO-A) on erythropoiesis has raised interest in its administration as an alternative. The existing evidence on the early use of EPO-A in the acute phase of trauma patients management consists of only 14 publications. The level of evidence of these studies and the number of treated patients was not found to be adequate to support its generalised use, despite their favourable results. Its safety profile, the preliminary proofs of its efficacy, and the additional cyto-protective properties of EPO-A strongly encourage further controlled studies assessing its use in the acute setting of initial trauma management.

PMID:: 19117559; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Related citations

Review Recombinant human erythropoietin therapy in critically ill Jehovah's Witnesses. [Pharmacotherapy. 2008]
Review Recombinant human erythropoietin therapy in critically ill Jehovah's Witnesses.
Ball AM, Winstead PS. Pharmacotherapy. 2008 Nov; 28(11):1383-90.
Review The contemporary approach to the care of Jehovah's witnesses. [J Trauma. 2008]
Review The contemporary approach to the care of Jehovah's witnesses.
Hughes DB, Ullery BW, Barie PS. J Trauma. 2008 Jul; 65(1):237-47.
Lessons learned from the outcome of bloodless emergency laparotomies on Jehovah's Witness women presenting in the extremis with ruptured uterus. [Arch Gynecol Obstet. 2009]
Lessons learned from the outcome of bloodless emergency laparotomies on Jehovah's Witness women presenting in the extremis with ruptured uterus.
Chigbu B, Onwere S, Kamanu C, Aluka C, Okoro O, Feyi-Waboso P, Onichakwe C. Arch Gynecol Obstet. 2009 Apr; 279(4):469-72. Epub 2008 Aug 2.
Anesthetic management for ascending aorta replacement in a patient who refused autologous transfusion for religious reasons. [J Anesth. 2009]
Anesthetic management for ascending aorta replacement in a patient who refused autologous transfusion for religious reasons.
Obara S, Nakagawa M, Takahashi S, Akatu M, Isosu T, Murakawa M. J Anesth. 2009; 23(3):436-8. Epub 2009 Aug 14.
Recombinant human erythropoietin in severe anaemia: issues of dosing and duration. [Anaesth Intensive Care. 2006]
Recombinant human erythropoietin in severe anaemia: issues of dosing and duration.
Charles A, Purtill M, Napolitano LM. Anaesth Intensive Care. 2006 Dec; 34(6):793-6.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

The role of erythropoietin in the acute phase of trauma management: evidence tod...
The role of erythropoietin in the acute phase of trauma management: evidence today.
Injury. 2009 Jan ;40(1):21-7. Epub 2008 Dec 30 .

PubMed
Therapeutic use of citrulline in cardiovascular disease.
Therapeutic use of citrulline in cardiovascular disease.
Cardiovasc Drug Rev. 2006 Fall-Winter ;24(3-4):275-90.

PubMed
A host cell membrane protein, golgin-97, is essential for poxvirus morphogenesis...
A host cell membrane protein, golgin-97, is essential for poxvirus morphogenesis.
Virology. 2007 Jun 5 ;362(2):421-7. Epub 2007 Feb 5 .

PubMed
L-arginine supplementation in peripheral arterial disease: no benefit and possib...
L-arginine supplementation in peripheral arterial disease: no benefit and possible harm.
Circulation. 2007 Jul 10 ;116(2):188-95. Epub 2007 Jun 25 .

PubMed
Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activ...
Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment.
J Immunol. 2003 May 15 ;170(10):4886-90.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: