J Muscle Res Cell Motil. 2008;29(6-8):213-9. Epub 2008 Dec 31.

Gestalt-binding of tropomyosin to actin filaments.

Source

Arbeitsgruppe Biophysik, Max Planck Institut für medizinische Forschung, Jahnstrasse 29, 69120, Heidelberg, Germany.

Abstract

We argue that the overall behavior of tropomyosin on F-actin cannot be easily discerned by examining thin filaments reduced to their smallest interacting units. In isolation, the individual interactions of actin and tropomyosin, by themselves, are too weak to account for the specificity of the system. Instead the association of tropomyosin on actin can only be fully explained after considering the concerted action of the entire acto-tropomyosin system. We propose that the low K ( a ) describing tropomyosin:actin interaction, when taken together with the form-fitting complementarity of tropomyosin strands on F-actin and the tendency for tropomyosin to polymerize end-to-end, make possible unique thin filament functions both locally and at higher levels of filament organization.

PMID:: 19116763; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Tropomyosin

Grant Support

LinkOut - more resources

Full Text Sources

Supplemental Content

Related citations

A comparison of muscle thin filament models obtained from electron microscopy reconstructions and low-angle X-ray fibre diagrams from non-overlap muscle. [J Struct Biol. 2006]
A comparison of muscle thin filament models obtained from electron microscopy reconstructions and low-angle X-ray fibre diagrams from non-overlap muscle.
Poole KJ, Lorenz M, Evans G, Rosenbaum G, Pirani A, Craig R, Tobacman LS, Lehman W, Holmes KC. J Struct Biol. 2006 Aug; 155(2):273-84. Epub 2006 May 7.
Tropomyosin length and two-stranded F-actin flexibility in the thin filament. [J Mol Biol. 1994]
Tropomyosin length and two-stranded F-actin flexibility in the thin filament.
Censullo R, Cheung HC. J Mol Biol. 1994 Oct 28; 243(3):520-9.
Troponin organization on relaxed and activated thin filaments revealed by electron microscopy and three-dimensional reconstruction. [J Mol Biol. 2001]
Troponin organization on relaxed and activated thin filaments revealed by electron microscopy and three-dimensional reconstruction.
Lehman W, Rosol M, Tobacman LS, Craig R. J Mol Biol. 2001 Mar 30; 307(3):739-44.
Review Cooperative binding of tropomyosin to actin. [Adv Exp Med Biol. 2008]
Review Cooperative binding of tropomyosin to actin.
Tobacman LS. Adv Exp Med Biol. 2008; 644:85-94.
Review Tropomyosins regulate the impact of actin binding proteins on actin filaments. [Adv Exp Med Biol. 2008]
Review Tropomyosins regulate the impact of actin binding proteins on actin filaments.
Lindberg U, Schutt CE, Goldman RD, Nyåkern-Meazza M, Hillberg L, Rathje LS, Grenklo S. Adv Exp Med Biol. 2008; 644:223-31.

See reviews... See all...

Cited by 10 PubMed Central articles

The recruitment of acetylated and unacetylated tropomyosin to distinct actin polymers permits the discrete regulation of specific myosins in fission yeast. [J Cell Sci. 2010]
The recruitment of acetylated and unacetylated tropomyosin to distinct actin polymers permits the discrete regulation of specific myosins in fission yeast.
Coulton AT, East DA, Galinska-Rakoczy A, Lehman W, Mulvihill DP. J Cell Sci. 2010 Oct 1; 123(Pt 19):3235-43. Epub 2010 Aug 31.
Electron microscopy and persistence length analysis of semi-rigid smooth muscle tropomyosin strands. [Biophys J. 2010]
Electron microscopy and persistence length analysis of semi-rigid smooth muscle tropomyosin strands.
Sousa D, Cammarato A, Jang K, Graceffa P, Tobacman LS, Li XE, Lehman W. Biophys J. 2010 Aug 4; 99(3):862-8.
How sequence directs bending in tropomyosin and other two-stranded alpha-helical coiled coils. [Protein Sci. 2010]
How sequence directs bending in tropomyosin and other two-stranded alpha-helical coiled coils.
Brown JH. Protein Sci. 2010 Jul; 19(7):1366-75.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Gestalt-binding of tropomyosin to actin filaments.
Gestalt-binding of tropomyosin to actin filaments.
J Muscle Res Cell Motil. 2008 ;29(6-8):213-9. Epub 2008 Dec 31 .

PubMed
Modulation of actin mechanics by caldesmon and tropomyosin.
Modulation of actin mechanics by caldesmon and tropomyosin.
Cell Motil Cytoskeleton. 2008 Feb ;65(2):156-64.

PubMed
Seroprevalence and risk factors for herpes simplex virus infection in a populati...
Seroprevalence and risk factors for herpes simplex virus infection in a population of HIV-infected patients in Canada.
Sex Transm Dis. 2009 Mar ;36(3):165-9.

PubMed
Inhibition of prostate cancer growth by muscadine grape skin extract and resvera...
Inhibition of prostate cancer growth by muscadine grape skin extract and resveratrol through distinct mechanisms.
Cancer Res. 2007 Sep 1 ;67(17):8396-405.

PubMed
Selective molecular imaging of viable cancer cells with pH-activatable fluoresce...
Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes.
Nat Med. 2009 Jan ;15(1):104-9. Epub 2008 Dec 7 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: